Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …

Mitochondria, as the powerhouse organelle of cells, are greatly involved in regulating cell
signaling pathways, including those related to the innate and acquired immune systems …

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in
neuronal differentiation, cell survival, and synaptic function in the peripheral and central …

Loneliness, or perceived social isolation, is a leading predictor of all-cause mortality and is
increasingly considered a public health epidemic afflicting significant portions of the general …

Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain various
biomolecules, including nucleic acids, proteins and lipids, and are manufactured and …

The physiological crosstalk between glucocorticoid and melatonin maintains neuronal
homeostasis in regulating circadian rhythms. However, the stress-inducing level of …

There has been a progressive increase in the prevalence of obesity and its comorbidities
such as type 2 diabetes and cardiovascular diseases worldwide. Recent studies have …