HIV-1 remains an incurable infection that is associated with substantial economic and
epidemiologic impacts. HIV-associated neurocognitive disorders (HAND) are commonly …

Genetic editing of induced pluripotent stem (iPS) cells represents a promising avenue for an
HIV cure. However, certain challenges remain before bringing this approach to the clinic …

Objectives: The discovery of induced pluripotent stem cells (iPSC) has brought promise to
regenerative medicine as it breaks the ethical barrier of using embryonic stem cells. Such …

CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats) is an
exponentially growing tool with wide-spread applications in therapeutics like gene …

Genome editing has enhanced our ability to understand the role of genetics in a number of
diseases by facilitating the development of more precise cellular and animal models to study …

Human immunodeficiency virus type 1 (HIV-1) is the causative agent of a progressive failure
in the host immune system, leading to acquired immunodeficiency syndrome (AIDS) …

Human immunodeficiency virus (HIV) is nowadays one of the major health problems
worldwide. Several strategies have been explored for the eradication of latent HIV-1 …

This thesis is part of a project that aims to build a new technology to make cell therapies
safer for medical applications. Most of the work on this technology was done by my …