Sodium–glucose cotransporter-2 inhibitors versus glucagon-like peptide-1 receptor agonists and the risk for cardiovascular outcomes in routine care patients with …

E Patorno, PT Htoo, RJ Glynn… - Annals of internal …, 2021 - acpjournals.org
Background: Both sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like
peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in placebo …

Metabolic spectrum of liver failure in type 2 diabetes and obesity: from NAFLD to NASH to HCC

H Kim, DS Lee, TH An, HJ Park, WK Kim… - International journal of …, 2021 - mdpi.com
Liver disease is the spectrum of liver damage ranging from simple steatosis called as
nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). Clinically …

Biomarker-based risk prediction of incident heart failure in pre-diabetes and diabetes

A Pandey, M Vaduganathan, KV Patel, C Ayers… - Heart Failure, 2021 - jacc.org
Objectives This study evaluated the application of a biomarker-based risk score to identify
individuals with dysglycemia who are at high risk for incident heart failure (HF) and to inform …

Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus …

P Gourdy, P Darmon, F Dievart, JM Halimi… - Cardiovascular …, 2023 - Springer
Due to their cardiovascular protective effect, glucagon-like peptide-1 receptor agonists (GLP-
1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent breakthrough …

Effects of metformin in heart failure: From pathophysiological rationale to clinical evidence

T Salvatore, R Galiero, A Caturano, E Vetrano… - Biomolecules, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a worldwide major health burden and heart failure (HF)
is the most common cardiovascular (CV) complication in affected patients. Therefore …

Emerging glucagon-like peptide 1 receptor agonists for the treatment of obesity

MM Jepsen, MB Christensen - Expert opinion on emerging drugs, 2021 - Taylor & Francis
Introduction: Obesity is a growing threat to public health, increasing risks of numerous
diseases and mortality, and impairing quality of life. If current trends continue, more than 1.1 …

Efficacy and safety of anti-hyperglycaemic drugs in patients with non-alcoholic fatty liver disease with or without diabetes: An updated systematic review of randomized …

A Mantovani, CD Byrne, E Scorletti, CS Mantzoros… - Diabetes & …, 2020 - Elsevier
Aim There are no approved drugs for the treatment of non-alcoholic fatty liver disease
(NAFLD). However, many randomized controlled trials (RCT) have examined the effect of …

Adult-onset autoimmune diabetes

R Buzzetti, E Maddaloni, J Gaglia, RD Leslie… - Nature reviews Disease …, 2022 - nature.com
Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

Non‐alcoholic fatty liver disease‐related risk of cardiovascular disease and other cardiac complications

CD Byrne, G Targher - Diabetes, Obesity and Metabolism, 2022 - Wiley Online Library
Abstract Background/Aim Non‐alcoholic fatty liver disease (NAFLD) affects approximately
25% of the global adult population. The aim of this narrative review is to describe the …

Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of …

EM Muzurović, Š Volčanšek… - Journal of …, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic …