Navigating the contested borders between myelodysplastic syndrome and acute myeloid leukemia

AJ Ambinder, AE DeZern - Frontiers in Oncology, 2022 - frontiersin.org
Myelodysplastic syndrome and acute myeloid leukemia are heterogeneous myeloid
neoplasms which arise from the accumulation of mutations in a myeloid stem cell or …

Precision medicine in myeloid malignancies: hype or hope?

S Upadhyay Banskota, N Khanal, RI Marar… - Current hematologic …, 2022 - Springer
Abstract Purpose of Review We review how understanding the fitness and comorbidity
burden of patients, and molecular landscape of underlying acute myeloid leukemia (AML) …

Allogeneic hematopoietic stem cell transplantation for adults with therapy-related acute myeloid leukaemia: a retrospective multicentre study on behalf of the SFGM …

G Rey, E Daguenet, P Bonjean, R Devillier… - Bone Marrow …, 2023 - nature.com
We report the results from a multicentre retrospective study of 220 adult patients who
underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related …

Impact of different chemotherapy regimens on intestinal mucosal injury assessed with bedside ultrasound: a study in 213 AML patients

E Benedetti, G Traverso, G Pucci, R Morganti… - Frontiers in …, 2023 - frontiersin.org
Introduction Neutropenic enterocolitis (NEC) is a life-threatening complication reported in
patients with acute myeloid leukemia (AML) following chemotherapy (CHT). Intensive …

Secondary acute myeloid leukemia: pathogenesis and treatment

D Capelli, D Menotti, A Fiorentini, F Saraceni… - Exon …, 2022 - exonpublications.com
Secondary acute myeloid leukemia includes acute myeloid leukemia that arises either from
a previous myeloid hematologic disease such as myelodysplastic syndrome, chronic …

Measurable residual disease in high-risk acute myeloid leukemia

T Cluzeau, RM Lemoli, J McCloskey, T Cooper - Cancers, 2022 - mdpi.com
Simple Summary Assessment of measurable residual disease (MRD) identifies small
numbers of acute myeloid leukemia (AML) cells that may remain after initiating treatment …

Reliable Identification and Interpretation of Single‐Cell Molecular Heterogeneity and Transcriptional Regulation using Dynamic Ensemble Pruning

Y Fan, Y Wang, F Wang, L Huang, Y Yang… - Advanced …, 2023 - Wiley Online Library
Unsupervised clustering is an essential step in identifying cell types from single‐cell RNA
sequencing (scRNA‐seq) data. However, a common issue with unsupervised clustering …

Comparison of scoring systems evaluating suitability for intensive chemotherapy in adults with acute myeloid leukemia—a Grand Ouest Against Leukemia (GOAL) …

C Desprez, J Riou, P Peterlin, T Marchand… - Leukemia, 2022 - nature.com
Several scoring systems have been developed to assess suitability of individual patients for
intensive acute myeloid leukemia (AML) therapy. We sought to compare the performance of …

Cost-Effectiveness Analyses in AML: What Have We Learned, How Should This Impact Patient Care, and What Needs to Be Done in the Future?

JP Bewersdorf, SF Huntington, AM Zeidan - Journal of the National …, 2023 - jnccn.org
Acute myeloid leukemia (AML) is the most common acute leukemia in adults in the United
States and has seen the approval of several novel agents over the past decade. Similar to …

Acute myeloid leukemia treatment in the elderly: a comprehensive review of the present and future

J Choi, M Shukla, M Abdul-Hay - Acta Haematol, 2023 - karger.com
Background: Acute myeloid leukemia (AML) is a disease of the hematopoietic system that
remains a therapeutic challenge despite advances in our understanding of the underlying …