Stem-cell-based embryo models for fundamental research and translation
Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
Mechanical regulation of early vertebrate embryogenesis
Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …
mechanical forces that shape the development of the entire embryo. Despite their …
Self-patterning of human stem cells into post-implantation lineages
Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …
and ethical limitations of working with embryonic samples. In the face of these difficulties …
Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …
geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) …
A 3D model of a human epiblast reveals BMP4-driven symmetry breaking
Breaking the anterior–posterior symmetry in mammals occurs at gastrulation. Much of the
signalling network underlying this process has been elucidated in the mouse; however …
signalling network underlying this process has been elucidated in the mouse; however …
Mechanisms of human embryo development: from cell fate to tissue shape and back
MN Shahbazi - Development, 2020 - journals.biologists.com
Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …
and function: the pillars of embryo development. Although model systems offer a window …
Self-organization of stem cells into embryos: a window on early mammalian development
Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …
acting at different scales of organization. In vivo studies are particularly challenging for …
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
[HTML][HTML] Human gastrulation: The embryo and its models
Technical and ethical limitations create a challenge to study early human development,
especially following the first 3 weeks of development after fertilization, when the fundamental …
especially following the first 3 weeks of development after fertilization, when the fundamental …
Human embryogenesis: a comparative perspective
C Gerri, S Menchero, SK Mahadevaiah… - Annual review of cell …, 2020 - annualreviews.org
Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …
mammalian model organisms. With the advent of low-input methods to investigate genetic …