siRNA drug delivery across the blood–brain barrier in Alzheimer's disease

MI Sajid, FS Sheikh, F Anis, N Nasim… - Advanced Drug Delivery …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …

Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer's disease

A Unnisa, NH Greig, MA Kamal - Neural Regeneration Research, 2023 - journals.lww.com
Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer's disease.
Treatment approaches have focused on the suppression, deferral, or dispersion of amyloid …

Protein and gene delivery systems for neurodegenerative disorders: where do we stand today?

PI Siafaka, ME Okur, PD Erim, EŞ Çağlar, E Özgenç… - Pharmaceutics, 2022 - mdpi.com
It has been estimated that every year, millions of people are affected by neurodegenerative
disorders, which complicate their lives and their caregivers' lives. To date, there has not …

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases

O Rice, A Surian, Y Chen - Journal of Tissue Engineering, 2022 - journals.sagepub.com
The blood-brain barrier (BBB) is the most specialized biological barrier in the body. This
configuration of specialized cells protects the brain from invasion of molecules and particles …

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

D Huang, W Liao, J Li, T Chen, X Wang… - Advanced Functional …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …

Emerging two-dimensional materials-based diagnosis of neurodegenerative diseases: Status and challenges

J Wu, W Dong, Z Zhang, J Liu, M Akioma, J Liu, Y Liu… - Nano Today, 2021 - Elsevier
Neurodegenerative diseases (NDs), conventionally characterized by multifarious impacts on
patients' cognitive skill, motor function and memory, have been brought into focus with the …

[HTML][HTML] siRNA therapeutics: future promise for neurodegenerative diseases

A Amiri, G Barreto, T Sathyapalan… - Current …, 2021 - ncbi.nlm.nih.gov
Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders,
are among the most prominent medical problems of the 21 st century. They are often …

Emerging paradigms in Alzheimer's Therapy

K Rajendran, AJ Sukumar, UM Krishnan - European Journal of …, 2024 - Elsevier
Alzheimer's disease is a neurodegenerative disorder that affects elderly, and its incidence is
continuously increasing across the globe. Unfortunately, despite decades of research, a …

A potential nine-lncRNAs signature identification and nomogram diagnostic model establishment for papillary thyroid cancer

JM Yao, JY Zhao, FF Lv, XB Yang… - Pathology and Oncology …, 2022 - por-journal.com
The purpose of our current study was to establish a long non-coding RNA (lncRNA)
signature and assess its prognostic and diagnostic power in papillary thyroid cancer (PTC) …

Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease

M Katta, BA Mathew, P Chaturvedi, A Ludhiadch… - Neurological …, 2023 - Springer
Neurological diseases (NDs) are one of the leading causes of disability and the second
leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and …