Oxidative stress, amyloid-β peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease

DA Butterfield, D Boyd-Kimball - Journal of Alzheimer's …, 2018 - content.iospress.com
Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

DJ Colacurcio, RA Nixon - Ageing research reviews, 2016 - Elsevier
Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

D Anastasiou, G Poulogiannis, JM Asara, MB Boxer… - Science, 2011 - science.org
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer
cell survival. We show that, in human lung cancer cells, acute increases in intracellular …

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

DA Butterfield, AM Swomley… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

[HTML][HTML] Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain

DA Butterfield, F Di Domenico, E Barone - Biochimica et Biophysica Acta …, 2014 - Elsevier
Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive …

A Tramutola, JC Triplett, F Di Domenico… - Journal of …, 2015 - Wiley Online Library
The clinical symptoms of Alzheimer disease (AD) include a gradual memory loss and
subsequent dementia, and neuropathological deposition of senile plaques and …

Mediterranean diet and mild cognitive impairment

N Scarmeas, Y Stern, R Mayeux, JJ Manly… - Archives of …, 2009 - jamanetwork.com
Background Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer
disease (AD), but its association with mild cognitive impairment (MCI) has not been …

Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders

G Scapagnini, V Sonya, AG Nader, C Calogero… - Molecular …, 2011 - Springer
In recent years, there has been a growing interest, supported by a large number of
experimental and epidemiological studies, for the beneficial effects of some phenolic …

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

MA Smith, X Zhu, M Tabaton, G Liu… - Journal of …, 2010 - content.iospress.com
It is now established that oxidative stress is one of the earliest, if not the earliest, change that
occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive …

Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms

M Singh, M Arseneault, T Sanderson… - Journal of agricultural …, 2008 - ACS Publications
Polyphenols are the most abundant antioxidants in diet. Indeed, fruits, vegetables,
beverages (tea, wine, juices), plants, and some herbs are loaded with powerful antioxidant …