The liposomal amphotericin B (AmB) formulation, AmBisome®, still represents the best
therapeutic option for cutaneous and visceral leishmaniasis. However, its clinical efficacy …

Taxus, also known as “gold in plants” because of the famous agents with emphases on
Taxol and Docetaxel, is a genus of the family Taxaceae, distributed almost around the world …

Lactoferrin is an 80 kDa monomeric glycoprotein that exhibits multitask activities. Lactoferrin
properties are of interest in the pharmaceutical field for the design of products with …

Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-
borne parasitic and fungal infections. However, its use, particularly in the developing world …

The main challenges associated with leishmaniasis chemotherapy are drug toxicity, the
possible emergence of resistant parasites, and a limited choice of therapeutic agents …

Abstract Treatment of visceral leishmaniasis (VL) is compromised by drug toxicity, high cost
and/or the emergence of resistant strains. Though canine vaccines are available, there are …

The second-line antileishmanial compound pentamidine is administered intramuscularly or,
preferably, by intravenous infusion, with its use limited by severe adverse effects, including …

A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards
identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids …

Clotrimazole is an FDA approved drug and is widely used as an antifungal agent. An
extensive body of research is available about its mechanism of action on various cell types …

Neglected tropical diseases transmitted by trypanosomatids include three major human
scourges that globally affect the world's poorest people: African trypanosomiasis or sleeping …