The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
The spatial organization of transcriptional control
A Hafner, A Boettiger - Nature Reviews Genetics, 2023 - nature.com
In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …
transcription start site of genes, but are frequently thousands to millions of base pairs distal …
[HTML][HTML] A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
J Morales, S Pujar, JE Loveland, A Astashyn, R Bennett… - Nature, 2022 - nature.com
Comprehensive genome annotation is essential to understand the impact of clinically
relevant variants. However, the absence of a standard for clinical reporting and browser …
relevant variants. However, the absence of a standard for clinical reporting and browser …
Recent advancements in molecular marker-assisted selection and applications in plant breeding programmes
Background DNA markers improved the productivity and accuracy of classical plant
breeding by means of marker-assisted selection (MAS). The enormous number of …
breeding by means of marker-assisted selection (MAS). The enormous number of …
Cis-regulatory sequences in plants: their importance, discovery, and future challenges
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …
function to coordinate responses to developmental and environmental cues is of paramount …
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Enhancer elements in the human genome control how genes are expressed in specific cell
types and harbor thousands of genetic variants that influence risk for common diseases …
types and harbor thousands of genetic variants that influence risk for common diseases …
Mechanisms and regulation of human mitochondrial transcription
BG Tan, CM Gustafsson, M Falkenberg - Nature Reviews Molecular Cell …, 2024 - nature.com
The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …
different cell types, but the basic mechanisms underlying this process are still poorly …
Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
DNA G-quadruplex structures: more than simple roadblocks to transcription?
J Robinson, F Raguseo, SP Nuccio… - Nucleic acids …, 2021 - academic.oup.com
It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …
gene promoters was first linked to the regulation of gene expression. Since then, the …
Organization and regulation of gene transcription
P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …