The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic
diagnosis of cancer is increasing as personalized cancer therapy requires accurate …

The interplay between an evolving cancer and a dynamic immune microenvironment
remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell …

Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained
images of TCGA samples remain underutilized. To highlight this resource, we present …

Currently, there is no established guidance on how to process and evaluate resected lung
cancer specimens after neoadjuvant therapy in the setting of clinical trials and clinical …

We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …

Background HER2-positive breast cancers usually contain large amounts of T-cell infiltrate.
We hypothesised that trastuzumab resistance in HER2-positive breast cancer could be …

Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths.
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …

Remarkable progress in molecular analyses has improved our understanding of the
evolution of cancer cells toward immune escape,,,–. However, the spatial configurations of …