The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Children with Down syndrome (DS) have a 10-to 20-fold greater predisposition to develop
acute leukemia compared to the general population, with a skew towards myeloid leukemia …

Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong
inter-individual variability in terms of developmental phenotypes and diagnosis of co …

Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused
by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood …

(1) Background: We sought to investigate the baseline lung and heart biology of the Dp16
mouse model of Down syndrome (DS) as a prelude to the investigation of recurrent …

Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21.
Among their complex clinical features, including musculoskeletal, neurological, and …

Microglia are brain-resident macrophages that shape neural circuit development and are
implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have …

XIST RNA is heavily studied for its role in fundamental epigenetics and X-chromosome
inactivation; however, the translational potential of this singular RNA has been much less …

Recent epidemiological studies suggest that individuals with Down syndrome are more
susceptible to SARS-CoV-2 infection and have higher rates of hospitalization and mortality …