Interferon-stimulated genes: a complex web of host defenses
WM Schneider, MD Chevillotte… - Annual review of …, 2014 - annualreviews.org
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
they are highly effective at resisting and controlling pathogens. In this review, we begin by …
Origins of HIV and the AIDS pandemic
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
HIV restriction factors and mechanisms of evasion
MH Malim, PD Bieniasz - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …
their associated biological principles and processes. These advances have not only …
Comparing HIV‐1 and HIV‐2 infection: Lessons for viral immunopathogenesis
S Nyamweya, A Hegedus, A Jaye… - Reviews in medical …, 2013 - Wiley Online Library
SUMMARY HIV‐1 and HIV‐2 share many similarities including their basic gene
arrangement, modes of transmission, intracellular replication pathways and clinical …
arrangement, modes of transmission, intracellular replication pathways and clinical …
LGP2 is a positive regulator of RIG-I–and MDA5-mediated antiviral responses
T Satoh, H Kato, Y Kumagai… - Proceedings of the …, 2010 - National Acad Sciences
RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors
(RLRs), RIG-I, and melanoma differentiation–associated gene 5 (MDA5) in the cytoplasm …
(RLRs), RIG-I, and melanoma differentiation–associated gene 5 (MDA5) in the cytoplasm …
Poor translatability of biomedical research using animals—A narrative review
LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …
at over 92%, where it has been for the past few decades. The majority of these failures are …
Animal models for HIV/AIDS research
T Hatziioannou, DT Evans - Nature Reviews Microbiology, 2012 - nature.com
The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …
challenges. Although the development of effective antiretroviral therapy has been a major …
IFITM proteins restrict viral membrane hemifusion
K Li, RM Markosyan, YM Zheng, O Golfetto… - PLoS …, 2013 - journals.plos.org
The interferon-inducible transmembrane (IFITM) protein family represents a new class of
cellular restriction factors that block early stages of viral replication; the underlying …
cellular restriction factors that block early stages of viral replication; the underlying …
Restriction factors: from intrinsic viral restriction to shaping cellular immunity against HIV-1
M Colomer-Lluch, A Ruiz, A Moris… - Frontiers in …, 2018 - frontiersin.org
Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …
blocking viral replication and propagation. In addition to interfering at critical steps of the …
Intrinsic host restrictions to HIV-1 and mechanisms of viral escape
V Simon, N Bloch, NR Landau - Nature immunology, 2015 - nature.com
To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …
co-opting mechanisms of cellular physiology while defeating restriction factors that are …