Toll-like receptor 4 (TLR4) is a pattern-recognizing receptor that can bind exogenous and
endogenous ligands. It is expressed by acute myeloid leukemia (AML) cells, several bone …

Bone mesenchymal stem cells (BMSCs) are crucial for bone tissue regeneration, the
mechanical microenvironment of hard tissues, including bone and teeth, significantly affects …

Oxidative stress from high levels of intracellular reactive oxygen species (ROS) has been
linked to various bone diseases. Previous studies indicate that mesenchymal stem cells …

Background There is growing evidence that extracellular vesicles (EVs) play a crucial role in
the paracrine mechanisms of transplanted human mesenchymal stem cells (hMSCs). Little is …

Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting
of these cells is considered both for malignant and non-malignant diseases. We analyzed …

The use of three-dimensional porous scaffolds derived from decellularized extracellular
matrix (ECM) is increasing for functional repair and regeneration of injured bone tissue …

Simple Summary The formation of normal blood cells in the bone marrow is supported by a
network of non-hematopoietic cells including connective tissue cells, blood vessel cells and …

Acute myeloid leukemia (AML) is a deadly form of leukemia with ineffective traditional
treatment and frequent chemoresistance-associated relapse. Personalized drug screening …

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations
in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and …

Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-
leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in …