Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …

COVID-19 vaccines: rapid development, implications, challenges and future prospects

S Kashte, A Gulbake, SF El-Amin III, A Gupta - Human cell, 2021 - Springer
COVID-19 has affected millions of people and put an unparalleled burden on healthcare
systems as well as economies throughout the world. Currently, there is no decisive therapy …

[HTML][HTML] T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

KJ Ewer, JR Barrett, S Belij-Rammerstorfer, H Sharpe… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective …

Sputnik V COVID-19 vaccine candidate appears safe and effective

I Jones, P Roy - The Lancet, 2021 - thelancet.com
Denis Logunov and colleagues1 report their interim results from a phase 3 trial of the
Sputnik V COVID-19 vaccine in The Lancet. The trial results show a consistent strong …

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

JR Barrett, S Belij-Rammerstorfer, C Dold, KJ Ewer… - Nature medicine, 2021 - nature.com
More than 190 vaccines are currently in development to prevent infection by the novel
severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while …

Efficacy and safety of COVID-19 vaccines in older people

RL Soiza, C Scicluna, EC Thomson - Age and ageing, 2021 - academic.oup.com
Several vaccines against coronavirus disease 2019 (COVID-19) are on the cusp of
regulatory approval. Their safety and efficacy in older people is critical to their success. Even …

Adverse events reported from COVID-19 vaccine trials: a systematic review

RJ Kaur, S Dutta, P Bhardwaj, J Charan… - Indian Journal of Clinical …, 2021 - Springer
COVID-19 infection originated in Wuhan, China in December 2019 and crippled human
health globally in no time. The public health emergency required urgent efforts to develop …

Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays

KR Bewley, NS Coombes, L Gagnon, L McInroy… - Nature protocols, 2021 - nature.com
Virus neutralization assays measure neutralizing antibodies in serum and plasma, and the
plaque reduction neutralization test (PRNT) is considered the gold standard for measuring …

COVID-19: coronavirus vaccine development updates

J Zhao, S Zhao, J Ou, J Zhang, W Lan, W Guan… - Frontiers in …, 2020 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2), a newly emerged coronavirus, and has been pandemic since …

[HTML][HTML] Novel approaches for vaccine development

MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …