Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …

Pathogen infections impose severe challenges in clinical practice, especially for patients
infected with antibiotic-resistant microbes. The thioredoxin (Trx) system in Gram-positive …

On the one hand, reactive oxygen species (ROS) are involved in the onset and progression
of a wide array of diseases. On the other hand, these are a part of signaling pathways …

Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including
myocardial ischemia, congenital heart disease, heart failure, hypertension, atherosclerosis …

Liver transplantation is currently recognized as the only effective therapeutic option for end-
stage liver disease. Hepatic ischemia–reperfusion injury (IRI) remains a major cause of graft …

Significance: Physiological levels of reactive oxygen and nitrogen species (ROS/RNS)
function as fundamental messengers for many cellular and developmental processes in the …

Abstract Objective Qili Qiangxin (QLQX), a compound herbal medicine formula, is used
effectively to treat congestive heart failure in China. However, the molecular mechanisms of …

An important pathophysiological consequence of pressure overload‐induced cardiac
hypertrophy is adverse cardiac remodeling, including structural changes in cardiomyocytes …

Diabetes mellitus is a non-communicable metabolic disease hallmarked by chronic
hyperglycemia caused by beta-cell failure. Diabetic complications affect the vasculature and …