Studying the human immune system is challenging. These challenges stem from the
complexity of the immune system itself, the heterogeneity of the immune system between …

Abstract Type 1 diabetes (T1D) is a chronic, progressive autoinflammatory disorder resulting
from the breakdown of self-tolerance and unrestrained β cell-reactive immune response …

Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way
of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that …

Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal
immune regulation, leading to damage to host organs. The complicated pathogenesis and …

Type 1 diabetes (T1D) is one of the most common chronic diseases of the endocrine system,
associated with several life-threatening comorbidities. While the etiopathogenesis of T1D …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune condition that affects millions of
people worldwide. Insulin pumps or injections are the standard treatment options for this …

Single-cell proteomics analysis requires sensitive, quantitatively accurate, widely
accessible, and robust methods. To meet these requirements, the Single-Cell ProtEomics …

To restore immune tolerance towards self-antigens, ASIT aims to establish a favourable
balance between T effector cells and T regulatory cells. Whilst most ASITs, including …

In this chapter, the authors summarize the current knowledge of possible trigger (s) of p‐cell
autoimmunity and factors affecting the progression to the clinical onset in individuals who …

Objective: Type 2 diabetes mellitus (T2DM) is a complex polygenic disease. The onset of the
disease is related to autoimmunity. However, how immune cells function in the peripheral …