In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

The capacity of cutaneous, including trigeminal endings, to detect chemicals is known as
chemesthesis or cutaneous chemosensation. This sensory function involves the activation of …

The peripheral terminals of primary sensory neurons detect histamine and non-histamine
itch-provoking ligands through molecularly distinct transduction mechanisms. It remains …

Dental pain is a common health problem that negatively impacts the activities of daily living.
Dentine hypersensitivity and pulpitis-associated pain are among the most common types of …

Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice.
Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild …

Due, in part, to the unique structure of the tooth, dental pain is initiated via distinct
mechanisms. Here we review recent advances in our understanding of inflammatory tooth …

The Transient Receptor Potential (TRP) channels family consists of seven different
subfamilies, namely TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML …

It is crucial for a living organism to recognize and discern potentially harmful noxious stimuli
from innocuous stimuli to avoid hazards in the environment. However, unnecessary or …

Capsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its
hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including …

QX-314 (N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage-dependent
sodium channels when applied internally to axons or neuronal cell bodies. Coapplication of …