The tetracycline antibiotic class has acquired new valuable members due to the optimisation
of the chemical structure. The first modern tetracycline introduced into therapy was …

Infections in the ICU are often caused by Gram-negative bacteria. When these
microorganisms are resistant to third-generation cephalosporines (due to extended …

Background We conducted this study to describe the clinical characteristics, microbiology,
and outcomes of patients treated with ceftazidime-avibactam (CZA) for a range of multidrug …

Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly around the world in
the past few years, posing great challenges to human health. The plasmid-mediated …

Carbapenem-resistant Enterobacterales (CRE) are a growing threat to human health
worldwide. CRE often carry multiple resistance genes that limit treatment options and …

Omadacycline is a novel aminomethylcycline antibiotic developed as a once-daily,
intravenous and oral treatment for acute bacterial skin and skin structure infection (ABSSSI) …

Resistance to antimicrobials and particularly multidrug resistance is one of the greatest
challenges in the health system nowadays. The continual increase in the rates of …

Carbapenemase-producing Enterobacteriaceae represent an increasing global threat
worldwide and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae …

Severe/MDR Gram-negative infections continue to be important infections due to their
impact on patient outcomes, especially in critically ill and immunocompromised hosts. The …

Bacterial resistance has become increasingly serious because of the widespread use and
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …