Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
DN Cooper, M Krawczak, C Polychronakos… - Human genetics, 2013 - Springer
Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
Gene-environment interaction and psychiatric disorders: Review and future directions
Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …
genetic and environmental factors. Most evidence for such gene-environment interaction …
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
Genotype-by-environment interaction (GEI) is a fundamental component in understanding
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …
smoking, potentially impacting the overall trait variance when investigating the genetic …
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
JK Goodrich, M Singer-Berk, R Son, A Sveden… - Nature …, 2021 - nature.com
Hundreds of thousands of genetic variants have been reported to cause severe monogenic
diseases, but the probability that a variant carrier develops the disease (termed penetrance) …
diseases, but the probability that a variant carrier develops the disease (termed penetrance) …
Gene× environment interactions: from molecular mechanisms to behavior
T Halldorsdottir, EB Binder - Annual Review of Psychology, 2017 - annualreviews.org
Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …
psychiatric disorders and may consequently have direct clinical implications. In this review …
Comparisons of polyexposure, polygenic, and clinical risk scores in risk prediction of type 2 diabetes
OBJECTIVE To establish a polyexposure score (PXS) for type 2 diabetes (T2D)
incorporating 12 nongenetic exposures and examine whether a PXS and/or a polygenic risk …
incorporating 12 nongenetic exposures and examine whether a PXS and/or a polygenic risk …
Adjustment for index event bias in genome-wide association studies of subsequent events
Following numerous genome-wide association studies of disease susceptibility, there is
increasing interest in genetic associations with prognosis, survival or other subsequent …
increasing interest in genetic associations with prognosis, survival or other subsequent …
[HTML][HTML] Statistical analysis for genome-wide association study
In the past few years, genome-wide association study (GWAS) has made great successes in
identifying genetic susceptibility loci underlying many complex diseases and traits. The …
identifying genetic susceptibility loci underlying many complex diseases and traits. The …