Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …

Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side
effects of morphine and related opioids—which include fatal respiratory depression—are …

Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective
analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Direct functionalization of natural products is important for studying the structure–activity and
structure–property relationships of these molecules. Recent advances in the transition‐metal …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Natural products found in Mitragyna speciosa, commonly known as kratom, represent
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …