Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification
This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …
neurogenesis and specification of the developing retina, with a focus on insights obtained …
Self-organization of the retina during eye development, retinal regeneration in vivo, and in retinal 3D organoids in vitro
EN Grigoryan - Biomedicines, 2022 - mdpi.com
Self-organization is a process that ensures histogenesis of the eye retina. This highly
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …
[HTML][HTML] Deciphering early human pancreas development at the single-cell level
Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors
Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …
Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
Direct reprogramming of retinal Müller glia is a promising avenue for replacing
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …
photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions …
Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina
Generation of neurons through direct reprogramming has emerged as a promising
therapeutic approach for treating neurodegenerative diseases. In this study, we present an …
therapeutic approach for treating neurodegenerative diseases. In this study, we present an …
Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina
B Dorgau, J Collin, A Rozanska, D Zerti… - Nature …, 2024 - nature.com
The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …
represent fundamental processes during retinal development. Herein, we provide a …
ASCL1 induces neurogenesis in human Müller glia
J Wohlschlegel, C Finkbeiner, D Hoffer, F Kierney… - Stem Cell Reports, 2023 - cell.com
In mammals, loss of retinal cells due to disease or trauma is an irreversible process that can
lead to blindness. Interestingly, regeneration of retinal neurons is a well established process …
lead to blindness. Interestingly, regeneration of retinal neurons is a well established process …
Integration of spatial and temporal patterning in the invertebrate and vertebrate nervous system
YC Chen, N Konstantinides - Frontiers in Neuroscience, 2022 - frontiersin.org
The nervous system is one of the most sophisticated animal tissues, consisting of thousands
of interconnected cell types. How the nervous system develops its diversity from a few neural …
of interconnected cell types. How the nervous system develops its diversity from a few neural …
Temporal regulation of neural diversity in Drosophila and vertebrates
The generation of neuronal diversity involves temporal patterning mechanisms by which a
given progenitor sequentially produces multiple cell types. Several parallels are evident …
given progenitor sequentially produces multiple cell types. Several parallels are evident …