Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain

D Mintoff, R Agius, F Benhadou, A Das… - Clinical and …, 2023 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of the pilosebaceous unit.
The typical patient with HS is characterized as someone with obesity, who smokes and who …

Secukinumab in the treatment of hidradenitis suppurativa

CL Snyder, RS Gibson, ML Porter, AB Kimball - Immunotherapy, 2023 - Taylor & Francis
The IL-17 pathways are involved in the pathophysiology of many inflammatory skin
conditions, including hidradenitis suppurativa. Secukinumab, an IL-17A inhibitor, has been …

Hidradenitis suppurativa presents a methylome dysregulation capable to explain the pro‐inflammatory microenvironment: Are these DNA methylations potential …

U Radhakrishna, U Ratnamala… - Journal of the …, 2023 - Wiley Online Library
Background Hidradenitis suppurativa (HS) is a chronic, systemic, inflammatory skin
condition with elusive pathogenesis that affects therapeutic intervention directly. Objective …

Hidradenitis suppurativa associated telomere‐methylome dysregulations in blood

U Radhakrishna, U Ratnamala… - Journal of the …, 2024 - Wiley Online Library
Background Hidradenitis suppurativa (HS) is a chronic debilitating disease with a significant
burden of both organic and psychological comorbidities. It has been shown that certain …

DNA methylation profiling and integrative multi-omics analysis of skin samples reveal important contribution of epigenetics and immune response in the pathogenesis …

L Liu, Y Xue, J Chen, Y Li, T Chen, X Pan, J Zhong… - Clinical …, 2023 - Elsevier
The regulatory effect of DNA methylation on the pathogenesis of acne vulgaris is completely
unknown. Herein we analyzed the DNA methylation profile in skin samples of acne vulgaris …

[HTML][HTML] Comparative diet-gut microbiome analysis in Crohn's disease and Hidradenitis suppurativa

P Cronin, S McCarthy, C Hurley, TS Ghosh… - Frontiers in …, 2023 - frontiersin.org
Introduction The chronic inflammatory skin disease Hidradenitis suppurativa (HS) is strongly
associated with Crohn's Disease (CD). HS and CD share clinical similarities and similar …

Cytochrome P450 genes mediated by DNA methylation are involved in the resistance to hidradenitis suppurativa

U Radhakrishna, U Ratnamala… - The Journal of …, 2023 - pubmed.ncbi.nlm.nih.gov
Cytochrome P450 Genes Mediated by DNA Methylation Are Involved in the Resistance to
Hidradenitis Suppurativa Cytochrome P450 Genes Mediated by DNA Methylation Are …

Hidradenitis suppurativa in Black and White patients-a clinical study

AS Byrd, AZ Rosenberg, WD Shipman… - European review for …, 2023 - air.unimi.it
OBJECTIVE: It is suggested that hidradenitis suppurativa (HS) is more prevalent and causes
greater morbidity in Black patients than in White. Clinical data are however lacking …

[HTML][HTML] An Updated Mutation Spectrum of the γ-Secretase Complex: Novel NCSTN Gene Mutation in an Indian Family with Hidradenitis Suppurativa and Acne …

U Ratnamala, NK Jain, DD Jhala… - Indian journal of …, 2023 - journals.lww.com
Background: Hidradenitis suppurativa (HS) is a complex, chronic inflammatory skin disorder
whose pathophysiology is poorly understood. Genetic studies have shown that HS is …

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

C Moltrasio, CA Silva, PM Tricarico, AV Marzano… - Frontiers in …, 2024 - frontiersin.org
MicroRNAs (miRNAs) play a crucial role in the early diagnosis of autoinflammatory
diseases, with Hidradenitis Suppurativa (HS) being a notable example. HS, an …