Molecular and genetic studies around the turn of this century have revolutionized the field of
cardiac development. We now know that the primary heart tube, as seen in the early embryo …

Congenital heart disease is the most common congenital defect observed in newborns.
Within the spectrum of congenital heart disease are left‐sided obstructive lesions (LSOLs) …

Master the concepts you need to know with Human Embryology and Developmental
Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow" road map" …

Background: Human-induced pluripotent stem cells (iPSCs) are a potentially unlimited
source for generation of cardiomyocytes (iPSC-CMs). However, current protocols for iPSC …

The genetic networks that govern vertebrate development are well studied, but how the
interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into …

Hypoplastic left heart syndrome (HLHS) is a serious congenital cardiovascular malformation
resulting in hypoplasia or atresia of the left ventricle, ascending aorta, and aortic and mitral …

Abstract Background Congenital heart diseases (CHDs) are the most common congenital
anomalies with an estimated prevalence of 8 in 1000 live births. CHDs occur as a result of …

Numerous cardiac transcription factors play overlapping roles in both the specification and
proliferation of the cardiac tissues and chambers during heart development. It has become …

Congenital heart disease (CHD) is the most common developmental abnormality, and is the
leading noninfectious cause of mortality in neonates. Increasing evidence demonstrates that …

Objectives Ventricular septal defect (VSD), one of the most common types of congenital
heart disease (CHD), results from a combination of environmental and genetic factors …