Organ-on-a-chip platforms serve as cost-efficient testbeds for screening pharmaceutical
agents, mimicking natural physiology, and studying disease. In the field of diabetes, the …

Supramolecular self-assembly of nanoscale filaments offers a vehicle to signal cells within
dense cell aggregates such as pancreatic islets. We previously developed a heparin …

This review aims to highlight the importance of the bidirectional influence of the extracellular
matrix (ECM) and immune cells in the context of type 1 diabetes mellitus (T1DM) and …

Biomaterial encapsulation of islets has been proposed to improve the long-term success of
islet transplantation by recreating a suitable microenvironment and enhancing cell-matrix …

Disruption of microenvironment and decrease in oxygen supply during isolation and culture
lead to pancreatic islet injury and their poor survival after transplantation. This study aimed …

While subcutaneous tissue has been proposed as a clinically relevant site for pancreatic
islet transplantation, a major issue of concern remains, which is its poor vascular state. In an …

Current treatment for type 1 diabetes mellitus requires daily insulin injections that fail to
produce physiological glycemic control. Islet cell transplantation has been proposed as a …

Early embryonic stem cell (ESC) differentiation is marked by the formation of three germ
layers from which all tissues types arise. Conventionally, ESCs are differentiated by altering …

Pancreatic islets are a highly vascularized entity, and their transplantation into diabetic
individuals requires optimal revascularization. In addition, β-cells in islets are extremely …

Background. Because the hepatic portal system may not be the optimal site for islet
transplantation, several extrahepatic sites have been studied. Here, we examine an …