An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

Although some signs of inflammation have been reported previously in patients with myalgic
encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Background: Inflammation is a part of the first line of defense of the body against invasive
pathogens, and plays a crucial role in tissue regeneration and repair. A proper inflammatory …

Background Infections have been hypothesised to increase the risk of dementia. Existing
studies have included a narrow range of infectious diseases, relied on short follow-up …

In the modern obesogenic environment, limiting calorie-dense food consumption is partially
dependent on the capacity of individuals to override visceral reactions to hyperpalatable and …

Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …