Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Induced pluripotent stem cells (iPSC s) are considered patient‐specific counterparts of
embryonic stem cells as they originate from somatic cells after forced expression of …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

Advanced therapies in medicine use stem cells, gene editing, and tissues to treat a wide
range of conditions. One of their goals is to stimulate endogenous repair of tissues and …

The therapeutic promise of induced pluripotent stem cells (iPSCs) has spurred efforts to
circumvent genome alteration when reprogramming somatic cells to pluripotency …

Reprogramming of somatic cells to induced pluripotent stem cells involves a dynamic
rearrangement of the epigenetic landscape. To characterize this epigenomic roadmap, we …

Early mammalian development entails transit through naive pluripotency towards post-
implantation epiblast, which subsequently gives rise to primordial germ cells (PGC), the …

The transcription factors OCT4 and SOX2 are required for generating induced pluripotent
stem cells (iPSCs) and for maintaining embryonic stem cells (ESCs). OCT4 and SOX2 …

The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse
embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296 …