Objectives: Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen
(RNS) species, along with the failure of balancing effects of endogenous antioxidant …

Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …

Abstract Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays
neuroprotective roles in neurodegenerative diseases. We aimed to explore the association …

As yet, there was no effective pharmacological therapy approved for non‐alcoholic fatty liver
disease (NAFLD). Here, we aimed to evaluate the therapeutic potential of puerarin against …

Obesity is an increasingly concerning global health issue, which is accompanied by
disruption of glucose and lipid metabolisms. The aim of this study was to uncover the …

In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …

Recent evidence suggests that nerve growth factor IB (Nur77) and nuclear receptor related1
(Nurr1) are differentially involved in dopaminergic neurodegeneration. Since memantine …

Simultaneous relief of the pain from body and brain remains an ongoing challenge. The aim
of the present study was to clarify whether plant-derived isoflavone puerarin could …

Liver fibrosis, which is the pathophysiologic process of the liver due to sustained wound
healing in response to chronic liver injury, will eventually progress to cirrhosis. Puerarin, a …

ABSTRACT Introduction: Traditional Chinese medicine (TCM) is a widely used
complementary alternative medicine approach. Although many aspects of its effectiveness …