Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)
Breast cancer resistance protein (BCRP/ABCG2) plays an important role in determining the
absorption and disposition of consumed xenobiotics including various drugs and dietary …
absorption and disposition of consumed xenobiotics including various drugs and dietary …
Effect of ABCG2/BCRP expression on efflux and uptake of gefitinib in NSCLC cell lines
Background BCRP/ABCG2 emerged as an important multidrug resistance protein, because
it confers resistance to several classes of cancer chemotherapeutic agents and to a number …
it confers resistance to several classes of cancer chemotherapeutic agents and to a number …
Current research method in transporter study
D Wang - Drug Transporters in Drug Disposition, Effects and …, 2019 - Springer
Transporters play an important role in the absorption, distribution, metabolism, and excretion
(ADME) of drugs. In recent years, various in vitro, in situ/ex vivo, and in vivo methods have …
(ADME) of drugs. In recent years, various in vitro, in situ/ex vivo, and in vivo methods have …
Influence of bioluminescence imaging dynamics by D-luciferin uptake and efflux mechanisms
Y Zhang, M Pullambhatla, J Laterra… - Molecular …, 2012 - journals.sagepub.com
Bioluminescence imaging (BLI) detects light generated by luciferase-mediated oxidation of
substrate and is used widely for evaluating transgene expression in cell-based assays and …
substrate and is used widely for evaluating transgene expression in cell-based assays and …
Altered expression of transporters, its potential mechanisms and influences in the liver of rodent models associated with diabetes mellitus and obesity
L Ma, L He, L Wang, L Li, X Lin, G Pan - European journal of drug …, 2016 - Springer
Diabetes mellitus is becoming an increasingly prevalent disease that concerns patients and
healthcare professionals worldwide. Among many anti-diabetic agents in clinical uses …
healthcare professionals worldwide. Among many anti-diabetic agents in clinical uses …
Cardiovascular drugs
S Riedmaier, UM Zanger - Metabolism of Drugs and Other …, 2012 - Wiley Online Library
A large number of drugs from different groups are used for the treatment of various
cardiovascular diseases. Here, we review how these drugs are metabolized in humans. This …
cardiovascular diseases. Here, we review how these drugs are metabolized in humans. This …
[图书][B] Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
S Ganguly - 2018 - search.proquest.com
Abstract Breast Cancer Resistant Protein (BCRP) and P-glycoprotein (PGP) are membrane-
bound efflux transporters that transport multiple chemical classes of compounds and act as …
bound efflux transporters that transport multiple chemical classes of compounds and act as …
Developing a novel strategy to treat glioblastoma: improving brain bioavailability of sorafenib with a synthetic flavonoid dimer to inhibit drug efflux in blood brain barrier
X Hu - 2018 - theses.lib.polyu.edu.hk
Glioblastoma (GBM) is the most common form of brain cancer with a short median survival
time (around 15 months). Chemotherapy is limited to temozolomide (TMZ) and resistance …
time (around 15 months). Chemotherapy is limited to temozolomide (TMZ) and resistance …
[图书][B] Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of …
D Ganguly - 2018 - search.proquest.com
Glioblastoma Multiforme (GBM) is an aggressive brain tumor, characterized by high cellular
heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of …
heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of …
Studies on the Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Dietary Phytochemicals: Implications for Phytochemical Bioavailability
K Tan - 2013 - researchspace.auckland.ac.nz
Breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette
(ABC) transporter superfamily. Ubiquitously expressed in the apical membrane of human …
(ABC) transporter superfamily. Ubiquitously expressed in the apical membrane of human …