[HTML][HTML] Role of oncostatin-M in ECM remodeling and plaque vulnerability
P Patel, V Rai, DK Agrawal - Molecular and Cellular Biochemistry, 2023 - Springer
Atherosclerosis is a multifactorial inflammatory disease characterized by the development of
plaque formation leading to occlusion of the vessel and hypoxia of the tissue supplied by the …
plaque formation leading to occlusion of the vessel and hypoxia of the tissue supplied by the …
[HTML][HTML] Oxidized low-density lipoproteins and lipopolysaccharides augment carotid artery plaque vulnerability in hypercholesterolemic microswine
Atherosclerosis is a chronic inflammatory disease and hypercholesterolemia is a risk factor.
This study aims to compare the potency of lipopolysaccharide (LPS) and oxidized low …
This study aims to compare the potency of lipopolysaccharide (LPS) and oxidized low …
[HTML][HTML] Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL …
RD Macarie, MM Tucureanu, L Ciortan, AM Gan… - Scientific Reports, 2023 - nature.com
Ficolin-2, recently identified in atherosclerotic plaques, has been correlated with future acute
cardiovascular events, but its role remains unknown. We hypothesize that it could influence …
cardiovascular events, but its role remains unknown. We hypothesize that it could influence …
Novel mediators regulating angiogenesis in diabetic foot ulcer healing
V Rai, H Le, DK Agrawal - Canadian Journal of Physiology and …, 2023 - cdnsciencepub.com
A non-healing diabetic foot ulcer (DFU) is a debilitating clinical problem amounting to
socioeconomic and psychosocial burdens. DFUs increase morbidity due to prolonged …
socioeconomic and psychosocial burdens. DFUs increase morbidity due to prolonged …
[HTML][HTML] Therapeutic Potential of Targeting p27kip1 in Plaque Vulnerability
J Trinh, J Shin, V Rai, DK Agrawal - Archives of internal medicine …, 2024 - ncbi.nlm.nih.gov
Atherosclerosis, a critical contributor to coronary artery diseases, involves the accumulation
of cholesterol, fibrin, and lipids within arterial walls, inciting inflammatory reactions …
of cholesterol, fibrin, and lipids within arterial walls, inciting inflammatory reactions …
[HTML][HTML] Oncostatin M, Serpins, and Oxidative Stress in Extracellular Matrix Remodeling and Arteriovenous Fistula Maturation
N DeMarco, V Rai, DR Wilson… - Cardiology and …, 2023 - ncbi.nlm.nih.gov
End-stage renal disease is a crippling diagnosis that generally requires dialysis to prolong
life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous …
life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous …
Single-cell landscape reveals NAMPT mediated macrophage polarization that regulate smooth muscle cell phenotypic switch in pulmonary arterial hypertension
Z Wen, L Jiang, F Yu, X Xu, M Chen, J Xue, P Zhu… - bioRxiv, 2023 - biorxiv.org
Rationale: Pulmonary arterial hypertension (PAH) is a progressive and lethal disease that
leads to elevated pulmonary vascular resistance and right ventricular failure. The phenotypic …
leads to elevated pulmonary vascular resistance and right ventricular failure. The phenotypic …
Low concentrations of TNF‐α in vitro transform the phenotype of vascular smooth muscle cells and enhance their survival in a three‐dimensional culture system
X Sun, H Jiang, Q Liu, C Xiao, J Xu, Y Wu… - Artificial …, 2024 - Wiley Online Library
Background Vascular smooth muscle cells (VSMCs) are commonly used as seed cells in
tissue‐engineered vascular constructions. However, their variable phenotypes and difficult …
tissue‐engineered vascular constructions. However, their variable phenotypes and difficult …
[HTML][HTML] Pathophysiology of Art eriovenous Fistula Maturation Failure
SH Kim - Journal of Korean Dialysis Access, 2023 - e-jkda.org
Arteriovenous fistula (AVF) maturation failure is a critical complication that can negatively
impact the quality of life for patients on hemodialysis. The pathophysiologic mechanism of …
impact the quality of life for patients on hemodialysis. The pathophysiologic mechanism of …