[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
K Cusi - Gastroenterology, 2012 - Elsevier
As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is
becoming a frequent cause of patient referral to gastroenterologists. There is a close link …
becoming a frequent cause of patient referral to gastroenterologists. There is a close link …
[HTML][HTML] TGF-β in progression of liver disease
S Dooley, P Ten Dijke - Cell and tissue research, 2012 - Springer
Transforming growth factor-β (TGF-β) is a central regulator in chronic liver disease
contributing to all stages of disease progression from initial liver injury through inflammation …
contributing to all stages of disease progression from initial liver injury through inflammation …
[PDF][PDF] Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER‐Medicare database
TM Welzel, BI Graubard, S Zeuzem, HB El‐Serag… - …, 2011 - Wiley Online Library
Incidence rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma
(ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor …
(ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor …
Urea cycle dysregulation in non-alcoholic fatty liver disease
F De Chiara, S Heebøll, G Marrone, C Montoliu… - Journal of …, 2018 - Elsevier
Background & Aims In non-alcoholic steatohepatitis (NASH), the function of urea cycle
enzymes (UCEs) may be affected, resulting in hyperammonemia and the risk of disease …
enzymes (UCEs) may be affected, resulting in hyperammonemia and the risk of disease …
[PDF][PDF] Ammonia scavenging prevents progression of fibrosis in experimental nonalcoholic fatty liver disease
F De Chiara, KL Thomsen, A Habtesion, H Jones… - …, 2020 - Wiley Online Library
Background and Aims In nonalcoholic fatty liver disease (NAFLD), fibrosis is the most
important factor contributing to NAFLD‐associated morbidity and mortality. Prevention of …
important factor contributing to NAFLD‐associated morbidity and mortality. Prevention of …
[HTML][HTML] LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease
Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic
fatty liver disease (NAFLD) pathogenesis and progression. Here, we aim to investigate the …
fatty liver disease (NAFLD) pathogenesis and progression. Here, we aim to investigate the …
[HTML][HTML] Tissue immunometabolism: development, physiology, and pathobiology
K Man, VI Kutyavin, A Chawla - Cell metabolism, 2017 - cell.com
Evolution of metazoans resulted in the specialization of cellular and tissue function. This was
accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their …
accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their …
Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease
AD Lake, P Novak, CD Fisher, JP Jackson… - Drug metabolism and …, 2011 - ASPET
Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological
changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The …
changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The …
[HTML][HTML] Differential lipotoxic effects of palmitate and oleate in activated human hepatic stellate cells and epithelial hepatoma cells
AM Hetherington, CG Sawyez, E Zilberman… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis
and hepatocellular carcinoma, alters the cellular composition of this organ. During late-stage …
and hepatocellular carcinoma, alters the cellular composition of this organ. During late-stage …