B cells are necessary to maintain disease activity in relapsing multiple sclerosis (MS) and
produce matrix metallopeptidase-9 (MMP-9), which disrupts the blood–brain barrier. MMP-9 …

Over the last decade, evidence condensed that B cells, B cell-derived plasma cells and
antibodies play a key role in the pathogenesis and progression of multiple sclerosis (MS). In …

Background The success of clinical trials of selective B cell depletion in patients with
relapsing multiple sclerosis (MS) indicates B cells are important contributors to peripheral …

A causal role for virus infection in the pathophysiology of multiple sclerosis (MS) has been
suggested and widely debated since the landmark epidemiologic studies of Kurtzke …

Despite advancements in genetic studies, it is difficult to understand and characterize the
functional relevance of disease-associated genetic variants, especially in the context of a …

Antibodies and oxidative stress are hallmarks of multiple sclerosis (MS) lesions. We aimed
to clarify the relation between them, their role in MS patients and to investigate their …

While it was long held that T cells were the primary mediators of multiple sclerosis (MS)
pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX) …

The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where
disease pathology is evident. Damaged CNS tissue is commonly associated with immune …

Introduction: The therapeutic utility of the anti-CD20 monoclonal antibodies (mAbs) is
currently being evaluated in multiple sclerosis (MS) in line with the better understanding of …

Primary vitreoretinal lymphoma (PVRL) is a high-grade lymphoma affecting the vitreous
and/or the retina. The vast majority of cases are histopathologically classified as diffuse …