Metabolic engineering entails target modification of cell metabolism to maximize the
production of a specific compound. For empowering combinatorial optimization in strain …

We present a synthetic gene circuit for decoupling cell growth from metabolite production
through autonomous regulation of enzymatic pathways by integrated modules that sense …

Synthetic biology uses living cells as the substrate for performing human-defined
computations. Many current implementations of cellular computing are based on the …

Promoter engineering is an enabling technology in metabolic engineering and synthetic
biology. As an indispensable part of synthetic biology, the promoter is a key factor in …

Malonyl-CoA is the basic building block for synthesizing a range of important compounds
including fatty acids, phenylpropanoids, flavonoids and non-ribosomal polyketides …

Highlights•Dynamic control is an attractive strategy to improve pathway efficiency.•A variety
of dynamic regulation tools have been developed so far.•Review of recent innovations in …

There is no design template more important than DNA. Within the sequences of this
exquisite substance lie the design plans for each of us and for every living organism …

Plants synthesize several thousand different polyphenols of which many have the potential
to aid in preventing or treating cancer, cardiovascular, and neurodegenerative diseases …

Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …

To mimic the delicately regulated metabolism in nature for improved efficiency, artificial and
customized regulatory components for dynamically controlling metabolic networks in …