Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor
genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and …

Ferroptosis is a newly characterized form of programmed cell death, which is driven by the
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …

Epstein–Barr virus (EBV) is an oncogenic herpesvirus associated with several cancers of
lymphocytic and epithelial origin,–. EBV encodes EBNA1, which binds to a cluster of 20 …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Ataxia-telangiectasia mutated (ATM) is a master kinase regulating DNA damage response
that is activated by DNA double-strand breaks. However, ATM is also directly activated by …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

Genome topology is tied to R-loop formation and genome stability. However, the regulatory
mechanism remains to be elucidated. By establishing a system to sense the connections …

Mitochondria are primarily involved in energy production through the process of oxidative
phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function …