Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Highlights•Regulation of non-centrosomal microtubule organization in neurons.•Role of
resilient acetylated microtubules in mechanosensation.•Patterning microtubule tracks to …

Axon initial segments (AISs) generate action potentials and regulate the polarized
distribution of proteins, lipids, and organelles in neurons. While the mechanisms of AIS Na+ …

Fast amoeboid migration is critical for developmental processes and can be hijacked by
cancer cells to enhance metastatic dissemination. This migratory behavior is tightly …

The cytoskeleton of a cell controls all the aspects of cell shape changes and motility from its
physiological functions for survival to reproduction to death. The structure and dynamics of …

Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders
characterized by lysosomal dysfunctions due to undegraded substrate accumulation. They …

Septins are conserved cytoskeletal proteins that regulate cell cortex mechanics. The
mechanisms of their interactions with the plasma membrane remain poorly understood …

The cytoskeleton occupies a central role in cellular immunity by promoting bacterial sensing
and antibacterial functions. Septins are cytoskeletal proteins implicated in various cellular …