Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

eNOS (endothelial nitric oxide synthase) is critically important enzyme responsible for
regulation of cardiovascular homeostasis. Under physiological conditions, constitutive eNOS …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

Increasing evidence suggests incomplete recovery of COVID-19 patients, who continue to
suffer from cardiovascular diseases, including cerebral vascular disorders (CVD) and …

Brain disorders represent a significant challenge in medical science due to the formidable
blood–brain barrier (BBB), which severely limits the penetration of conventional …

Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by amyloid β
(Aβ) peptide deposition within the walls of medium to small-caliber blood vessels, cerebral …

Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal
transduction. Under stressful conditions, it can be generated from de novo synthesis …

This aim of this editorial is to highlight progress made in brain barrier and brain fluid
research in 2022. It covers studies on the blood-brain, blood-retina and blood-CSF barriers …

Objective The purpose of our study was to investigate the association of obesity status
change with hypertension onset based on a community-based longitudinal cohort study in …