The recent explosion of transgenic zebrafish lines in the literature demonstrates the value of
this model system for detailed in vivo analysis of gene regulation and morphogenetic …

Hepatitis B virus envelope L particles form hollow nanoparticles displaying a peptide that is
indispensable for liver-specific infection by hepatitis B virus in humans. Here we …

Gene therapy holds great promise. Somatic gene therapy has the potential to treat a wide
range of disorders, including inherited conditions, cancers, and infectious diseases. Early …

Several new classes of pyridinium cationic lipids were synthesized and tested as gene
delivery agents. They were obtained through a procedure that generates simultaneously the …

Three series of pyridinium cationic lipids useful as nonviral gene delivery agents were
prepared by reaction of pyrylium salts with aminodiols, followed by acylation with fatty acyl …

Over the last century, medicine has come out of the" black bag" and emerged as one of the
most dynamic and advanced fields of development in science and technology. Today …

(57) ABSTRACT A method for engineering and utilizing large DNA vectors to target, via
homologous recombination, and modify, in any desirable fashion, endogenous genes and …

Transgenic animal mammary gland bioreactors are used to produce recombinant proteins.
However, it is difficult to validate whether these transgenic domestic animals are able to …

The invention discloses methods for the generation of chimaeric human-non-human
antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and …

2013-07-29 Assigned to REGENERON PHARMACEUTICALS, INC. reassignment
REGENERON PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …