Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

Background Enterobacterales are among the most common causes of bacterial infections in
the community and among hospitalized patients, and multidrug-resistant (MDR) strains have …

Objectives Cefepime remains an important antibiotic for severe bacterial infections, yet some
meta-analyses have shown elevated mortality among patients randomized to it. Therapeutic …

耐药菌的传播严重威胁人类健康, 目前耐药问题日益加剧, 给医疗卫生造成极大负担.
加强耐药菌感染的预防, 控制和诊疗能力建设是医疗机构防控耐药菌感染传播的重要内容 …

Introduction: Not enough data exist to inform the optimal duration and type of antimicrobial
therapy against GN infections in critically ill patients. Methods: Narrative review based on a …

The burden of antibiotic-resistant infections among Gram-negative bacteria is increasing.
Resistance to third-generation cephalosporins (3GCs) in Enterobacteriaceae is mainly …

Enmetazobactam, formerly AAI101, is a novel penicillanic acid sulfone extended-spectrum β-
lactamase (ESBL) inhibitor. The combination of enmetazobactam with cefepime has entered …

The treatment of urinary tract infections (UTIs) has been complicated by the emergence of
multidrug-resistant, β-lactamase-expressing pathogens. As a result of the limited treatment …