Despite significant improvements in diagnosis, surgical techniques, and advancements in
general patient care, the majority of deaths from cancer are caused by the metastases …

Cancer therapy directed at specific, frequently occurring molecular alterations in signaling
pathways of cancer cells has been validated through the clinical development and …

Ovarian carcinomas have a poor prognosis, often associated with multifocal ip
dissemination accompanied by intense neovascularization. To examine tumor angiogenesis …

Background The integrin αvβ3 plays an important role in angiogenesis and tumor cell
metastasis, and is currently being evaluated as a target for new therapeutic approaches …

Angiogenesis is essential for both primary and metastatic tumor growth. Tumor blood vessel
formation is complex and regulated by many factors. Ovarian carcinomas have a poor …

The therapeutic potential of targeting the tumor vascular supply is now widely recognized.
Intense research and development activity has resulted in a variety of investigational agents …

Statins, which have been introduced to the clinic for the treatment of hypercholesterolemia,
are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase …

Purpose: Given the complex tumor microenvironment, targeting multiple cellular
components may be the most effective cancer treatment strategy. Therefore, we tested …

As a link between exercise and metabolism, irisin is assumed to be involved in increased
total body energy expenditure, reduced body weight, and increased insulin sensitivity …

Purpose Due to the restricted expression of α v β 3 in tumours, α v β 3 is considered a
suitable receptor for tumour targeting. In this study the α v β 3-binding characteristics of 68 …