Programmed cell death: the pathways to severe COVID-19?

SM Bader, JP Cooney, M Pellegrini… - Biochemical …, 2022 - portlandpress.com
Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …

[HTML][HTML] Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19?

K Saleki, P Alijanizadeh, A Azadmehr - Biomedicine & Pharmacotherapy, 2023 - Elsevier
A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …

[HTML][HTML] NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel

N Krinsky, S Sizikov, S Nissim, A Dror, A Sas… - Journal of Thrombosis …, 2023 - Elsevier
Background COVID-19 severity and its late complications continue to be poorly understood.
Neutrophil extracellular traps (NETs) form in acute COVID-19, likely contributing to morbidity …

COVID-19 coagulopathy: from pathogenesis to treatment

T Alnima, MMG Mulder, BCT van Bussel… - Acta …, 2022 - karger.com
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a pandemic at the end of
2019 and continues to exert an unfavorable worldwide health impact on a large proportion …

Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

JS Cavalcante, DEG de Almeida… - International Journal of …, 2023 - mdpi.com
Snakebite envenoming represents a major health problem in tropical and subtropical
countries. Considering the elevated number of accidents and high morbidity and mortality …

NETosis and nucleosome biomarkers in septic shock and critical COVID-19 patients: an observational study

L Morimont, M Dechamps, C David, C Bouvy, C Gillot… - Biomolecules, 2022 - mdpi.com
Background: Neutrophil extracellular traps'(NETs') formation is a mechanism of defense that
neutrophils deploy as an alternative to phagocytosis, to constrain the spread of …

[HTML][HTML] Intestinal barrier dysfunction as a key driver of severe COVID-19

EP Tsounis, C Triantos, C Konstantakis… - World Journal of …, 2023 - ncbi.nlm.nih.gov
The intestinal lumen harbors a diverse consortium of microorganisms that participate in
reciprocal crosstalk with intestinal immune cells and with epithelial and endothelial cells …

Neutrophil extracellular traps in severe SARS-CoV-2 infection: A possible impact of LPS and (1→ 3)-β-d-glucan in blood from gut translocation

S Saithong, N Worasilchai, W Saisorn… - Cells, 2022 - mdpi.com
Due to limited data on the link between gut barrier defects (leaky gut) and neutrophil
extracellular traps (NETs) in coronavirus disease 2019 (COVID-19), blood samples of …

Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement …

F Ciccosanti, M Antonioli, A Sacchi, S Notari, A Farina… - Clinical proteomics, 2022 - Springer
Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …

Immune response induced by novel coronavirus infection

Y Sun, Y Zou, H Wang, G Cui, Z Yu… - Frontiers in Cellular and …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 has been prominent around the world since it was first …