Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Activated fibroblasts in cancer: Perspectives and challenges
G Caligiuri, DA Tuveson - Cancer cell, 2023 - cell.com
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …
popular research area over the past decade. As important players in many aspects of tumor …
Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
Clinical and therapeutic relevance of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …
versatile, plastic and resilient cells that are actively involved in cancer progression through …
Cancer-associated fibroblasts: from basic science to anticancer therapy
D Yang, J Liu, H Qian, Q Zhuang - Experimental & Molecular Medicine, 2023 - nature.com
Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …
Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
RL Barrett, E Puré - Elife, 2020 - elifesciences.org
Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …
Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …
Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
Z Xiao, L Todd, L Huang, E Noguera-Ortega… - Nature …, 2023 - nature.com
The desmoplastic stroma in solid tumors presents a formidable challenge to
immunotherapies that rely on endogenous or adoptively transferred T cells, however, the …
immunotherapies that rely on endogenous or adoptively transferred T cells, however, the …
Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer–associated fibroblasts
Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the
origins and functions of distinct CAF subtypes remain poorly understood. The abundant and …
origins and functions of distinct CAF subtypes remain poorly understood. The abundant and …
The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis
Background & Aims Cancer-associated fibroblasts (CAFs) play an important role in
colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However …
colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However …