Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells

RP Jajosky, SC Wu, PG Jajosky… - Tropical Medicine and …, 2023 - mdpi.com
Plasmodium knowlesi (Pk) causes zoonotic malaria and is known as the “fifth human
malaria parasite”. Pk malaria is an emerging threat because infections are increasing and …

Plasmodium knowlesi infection is associated with elevated circulating biomarkers of brain injury and endothelial activation

C Bertran-Cobo, E Dumont, N Rafieqin Noordin… - medRxiv, 2024 - medrxiv.org
Introduction: Malaria remains a major public health concern with substantial morbidity and
mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge …

Plasmodium knowlesi: New threat to Humans.

A Raza, SW Khan, S Aqeel… - Journal of Pure & …, 2023 - search.ebscohost.com
Plasmodium knowlesi is a parasite that can spread from animals to humans. Over the past
20 years, scientists have become more and more interested in this parasite. This parasitic …

Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance

MJ Grigg, T William, KA Piera, GS Rajahram, J Jelip… - Malaria Journal, 2018 - Springer
Abstract Background Spreading Plasmodium falciparum artemisinin drug resistance
threatens global malaria public health gains. Limited data exist to define the extent of P …

[HTML][HTML] Improved limit of detection for zoonotic Plasmodium knowlesi and P. cynomolgi surveillance using reverse transcription for total nucleic acid preserved …

KA Braima, KA Piera, IND Lubis, R Noviyanti… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background: Zoonotic P. knowlesi and P. cynomolgi symptomatic and asymptomatic
infections occur across endemic areas of Southeast Asia. Most infections are low …

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

JR Loughland, T Woodberry, D Oyong, KA Piera… - Malaria Journal, 2021 - Springer
Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-
like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell …

Plasmodium knowlesi – Clinical Isolate Genome Sequencing to Inform Translational Same-Species Model System for Severe Malaria

DR Oresegun, C Daneshvar… - Frontiers in cellular and …, 2021 - frontiersin.org
Malaria is responsible for unacceptably high morbidity and mortality, especially in Sub-
Saharan African Nations. Malaria is caused by member species' of the genus Plasmodium …

A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria

SH Apte, G Minigo, PL Groves… - Clinical & …, 2020 - Wiley Online Library
Objective CD4+ T cells are critical mediators of immunity to Plasmodium spp. infection, but
their characteristics during malarial episodes and immunopathology in naturally infected …

[HTML][HTML] Is the rise of simian zoonotic malarias a public health problem caused by humans? A review of simian malaria in humans

SD Woolley, NJ Beeching, DG Lalloo, GS Rajahram - IJID One Health, 2023 - Elsevier
Infections caused by Plasmodium falciparum, P. vivax and P. malariae have decreased
globally following the successful roll-out of malaria elimination strategies. However, there …

Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.

J Westaway, E Diez Benavente, S Auburn, M Kucharski… - bioRxiv, 2024 - biorxiv.org
Sabah, Malaysia, has amongst the highest burden of human Plasmodium knowlesi infection
in the country, associated with increasing encroachment on the parasite's macaque host …