OBJECTIVE: To assess whether oral ketamine is safe at higher dosages for sedating
children and whether it may be an option for the control of chronic pain in children. STUDY …

Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from
traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubiaceae). The aim of the …

Converging evidence shows that the acute administration of a sub-anaesthetic dose
ketamine produces fast-acting and robust antidepressant properties in patients suffering …

Ketamine is a drug largely used in clinical practice as an anesthetic and it can also be used
as an analgesic to manage chronic pain symptoms. Despite its interactions with several …

Heart failure with preserved ejection fraction (HFpEF) is currently untreated. Therapeutics
development demands effective diagnosis of diastolic dysfunction in animal models …

Background and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …

Ketamine has been widely used as an analgesic and produces dissociative anesthetic
effects. The antinociceptive effects of ketamine have been studied, but the involvement of …

Previous report indicated that nicorandil potentiated morphine antinociception and
attenuated hepatic injury in liver fibrotic rats. Herein, the underlying mechanisms of …

BACKGROUND: Several studies have demonstrated antinociception induced by exercise;
however, the specific mechanisms for this effect are not well understood. Thus, we …

Nitric oxide (NO) is a free radical gas in the biological system, which is produced by nitric
oxide synthase (NOS) family. NO acts as a biological mediator and plays important roles in …