Background. The mechanism for pain associated with intravenous administration of propofol
is believed to be related to the release of nitric oxide. We hypothesized that pain following …

The molecular modification and synthesis of compounds is vital to discovering drugs with
desirable pharmacological and toxicity profiles. In response to pyrazole compounds' …

Ketamine, an NMDA receptor antagonist, has been approved to have analgesic effects. It is
known that nitric oxide pathway is involved in antinociception but with dual effects. In this …

Background Cannabidiol (CBD) is the second most abundant pharmacologically active
component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no …

Bckground Aripiprazole is an antipsychotic drug used to treat schizophrenia and bipolar
disorder. Recently, its peripheral analgesic component was evaluated, however, the …

Objective To investigate the contribution of K+ channels on peripheral antinociception
induced by ketamine. Study design Prospective experimental study. Animals 110 male …

Objective: To study, the effect of prophylactic ketamine (K) gargle in reduction of post-
operative sore throat (POST) following endotracheal intubation. Materials and Methods: 90 …

A growing series of clinical trials and case series now suggest that ketamine—originally
used as an anesthetic agent—potentially offers an exciting new treatment option for severe …

Abstract Background & Objective: Sore throat is a common morbidity following tracheal
intubation in the post operative period. Our aim was to compare ketamine nebulisation with …

The N-methyl-d-aspartate (NMDA) receptor, an ionotropic glutamate receptor, may play a
significant role in the development and maintenance of an inflammatory pain. Activation of …