Films for wound healing fabricated using a solvent casting technique
FV Borbolla-Jiménez, SI Peña-Corona, SJ Farah… - Pharmaceutics, 2023 - mdpi.com
Wound healing is a complex process that involves restoring the structure of damaged
tissues through four phases: hemostasis, inflammation, proliferation, and remodeling …
tissues through four phases: hemostasis, inflammation, proliferation, and remodeling …
Automation and data-driven design of polymer therapeutics
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …
structural parameters such as length, composition, architecture, and valency. To facilitate …
The antisolvent coprecipitation method for enhanced bioavailability of poorly water-soluble drugs
J Zhang, M Liu, Z Zeng - International Journal of Pharmaceutics, 2022 - Elsevier
In recent years, poorly water-soluble drug candidates in the drug development pipeline have
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …
been a challenging issue for the pharmaceutical industry. Many delivery systems, such as …
Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics …
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are
desirable for improving oral absorption of amorphous solid dispersions. The present study …
desirable for improving oral absorption of amorphous solid dispersions. The present study …
[HTML][HTML] Polymer stabilized, phenytoin-loaded nanomicelles as promising nanocarriers: In silico and in vitro evaluations
Many drugs currently used in clinics to treat different diseases show low solubilities in
aqueous solutions and must be then administered with the aid of organic solvents within the …
aqueous solutions and must be then administered with the aid of organic solvents within the …
Continuous manufacturing and molecular modeling of pharmaceutical amorphous solid dispersions
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …
Bottlebrush polymer excipients enhance drug solubility: influence of end-group hydrophilicity and thermoresponsiveness
ML Ohnsorg, PC Prendergast, LL Robinson… - ACS Macro …, 2021 - ACS Publications
Bottlebrush polymers have great potential as vehicles to noncovalently sequester, stabilize,
and deliver hydrophobic small molecule actives. To this end, we synthesized a poly (N …
and deliver hydrophobic small molecule actives. To this end, we synthesized a poly (N …
Molecular simulation and statistical learning methods toward predicting drug–polymer amorphous solid dispersion miscibility, stability, and formulation design
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug
delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API …
delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API …
Amorphous solid dispersions and the contribution of nanoparticles to in vitro dissolution and in vivo testing: Niclosamide as a case study
We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …
Physical stability of amorphous pharmaceutical solids: Nucleation, crystal growth, phase separation and effects of the polymers
Q Shi, F Li, S Yeh, Y Wang, J Xin - International journal of pharmaceutics, 2020 - Elsevier
Compared to their crystalline forms, amorphous pharmaceutical solids present marvelous
potential and advantages for effectively improving the oral bioavailability of poorly water …
potential and advantages for effectively improving the oral bioavailability of poorly water …