Crystallinity in an amorphous solid dispersion (ASD) may negatively impact dissolution
performance by causing lost solubility advantage and/or seeding crystal growth leading to …

The amorphous form of a drug can greatly improve the solubility and rates of dissolution for
enhancing oral bioavailability. However, amorphous drugs tend to crystallize thus negating …

Understanding the dissolution mechanisms of amorphous solid dispersions (ASDs) and
being able to link enhanced drug exposure with process parameters are key when …

Polysaccharides are ubiquitous, generally benign in nature, and compatible with many
tissues in biomedical situations, making them appealing candidates for new materials such …

Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by
preparing ternary solid dispersion (TSD) systems containing alkalizers, and to explore the …

Characterization of nanoscale changes in the atomic structure of amorphous materials is a
profound challenge. Established X-ray and neutron total scattering methods typically provide …

Introduction Self-emulsifying drug delivery systems (SEDDS) are a promising strategy to
improve the oral bioavailability of poorly water-soluble drugs (PWSD). However, poor drug …

Amorphous solid dispersions (ASDs) utilize the kinetic stability of the amorphous state to
stabilize drug molecules within a glassy polymer matrix. Therefore, understanding the glassy …

The amorphous form of a drug usually exhibits higher solubility, faster dissolution rate, and
improved oral bioavailability in comparison to its crystalline forms. However, the amorphous …