Small-angle scattering (SAS) is a versatile analytical technique that provides detailed
structural information from a sample at the length scale of nanometers. In this overview, we …

In pharmaceutical oral drug delivery development, about 90% of drugs in the pipeline have
poor aqueous solubility leading to severe challenges with oral bioavailability and translation …

Inhibiting surface crystallization is an interesting strategy to enhance the physical stability of
amorphous solid dispersions (ASDs), still preserving high drug loads. The aim of this study …

The objective of the present study was to evaluate the use of artificial neural networks
(ANNs) in the development of a new chemometric model that will be able to simultaneously …

Amorphous solid dispersions (ASDs) of crystallizable drugs and polymer excipients are
attractive for enhancing the solubility and bioavailability of hydrophobic drug molecules. In …

Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-
established solubility enhancement strategy for poorly soluble drugs. Recently, two …

Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers
potential advantages regarding the minimization of physical stability issues, there is still a …

Poorly aqueous soluble active pharmaceutical ingredients are highly risky development
candidates and remain a concern of pharmaceutical industries in drug discovery and …

This study aimed to produce nanoparticles with reduced crystallinity by using a combination
method. The effect of solid-state transition (different drying processes) coupled with particle …

It is now recognized that a number of excipients previously considered to be “inert” have the
capacity to alter drug oral bioavailability through a range of in vivo effects. The various …