It is now recognized that a number of excipients previously considered to be “inert” have the
capacity to alter drug oral bioavailability through a range of in vivo effects. The various …

Bead coating or fluid-bed coating serves as an auspicious solvent-based amorphous solid
dispersion (ASD) manufacturing technique in respect of minimization of potential physical …

Carbamazepine (CBZ), a widely used antiepileptic drug, is known for its therapeutic efficacy
but exhibits suboptimal physicochemical characteristics, including limited bioavailability, low …

An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is
to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble …

The aim of this paper was to investigate whether a surface coating technique could be
developed that can predict the phase behavior of amorphous solid dispersions (ASDs) …

Polymeric materials have realized a broad range of applications in the biomedical world due
to their customizability, innocuity, and their ability to mimic biomacromolecules. Amphiphilic …

Drug products often make use of formulation technologies such as amorphous solid
dispersions (ASDs) to overcome solubility and bioavailability challenges associated with …

Polymerization induced self-assembly (PISA) provides a facile platform for encapsulating
therapeutics within block copolymer nanoparticles. Performing PISA in the presence of a …

The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of
significant importance for establishing a therapeutic effect in patients. However, the current …

NEW APPLICATIONS OF HOT MELT EXTRUSION TECHNIQUES FOR ADVANCING ORAL
DRUG DELIVERY Page 1 NEW APPLICATIONS OF HOT MELT EXTRUSION TECHNIQUES …