Synaptic compensatory plasticity in Alzheimer's disease
The loss of excitatory synapses is known to underlie the cognitive deficits in Alzheimer's
disease (AD). Although much is known about the mechanisms underlying synaptic loss in …
disease (AD). Although much is known about the mechanisms underlying synaptic loss in …
Targets, trials and tribulations in Alzheimer therapeutics
R Gharat, G Dixit, M Khambete, A Prabhu - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
abnormal accumulation of extracellular amyloid beta senile plaques and intracellular …
abnormal accumulation of extracellular amyloid beta senile plaques and intracellular …
Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease
N Jury-Garfe, J Redding-Ochoa, Y You, P Martínez… - Acta …, 2024 - Springer
Abstract Asymptomatic Alzheimer's disease (AsymAD) describes the status of individuals
with preserved cognition but identifiable Alzheimer's disease (AD) brain pathology (ie, beta …
with preserved cognition but identifiable Alzheimer's disease (AD) brain pathology (ie, beta …
[HTML][HTML] Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets
A Cordeiro, C Gomes, J Bicker, A Fortuna - Drug Discovery Today, 2024 - Elsevier
As the global population ages, the need to prolong lifespan and healthspan becomes
increasingly imperative. Understanding the molecular determinants underlying cognitive …
increasingly imperative. Understanding the molecular determinants underlying cognitive …
The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer's Disease
JA Zegarra-Valdivia, J Pignatelli, A Nuñez… - International Journal of …, 2023 - mdpi.com
Despite decades of intense research, disease-modifying therapeutic approaches for
Alzheimer's disease (AD) are still very much needed. Apart from the extensively analyzed …
Alzheimer's disease (AD) are still very much needed. Apart from the extensively analyzed …
Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington's Disease
DA Simmons, NP Belichenko… - Journal of Huntington's …, 2023 - content.iospress.com
Background: Loss of neurotrophic support in the striatum, particularly reduced brain-derived
neurotrophic factor (BDNF) levels, contributes importantly to Huntington's disease (HD) …
neurotrophic factor (BDNF) levels, contributes importantly to Huntington's disease (HD) …
Vertigoheel promotes rodent cognitive performance in multiple memory tests
K Ott, T Heikkinen, KK Lehtimäki, K Paldanius… - Frontiers in …, 2023 - frontiersin.org
Introduction Cognitive impairment associated with old age or various brain disorders may be
very disabling for affected individuals, placing their carers and public health services under …
very disabling for affected individuals, placing their carers and public health services under …
New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop
MA Telpoukhovskaia, TJ Murdy… - … Research & Clinical …, 2024 - Wiley Online Library
Abstract INTRODUCTION In September 2022, The Jackson Laboratory Center for
Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading …
Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading …
[引用][C] Alzheimer's Disease: Effects on brain circuits and synapses
TH Ch'ng, GJ Augustine - Seminars in cell & …, 2023 - pubmed.ncbi.nlm.nih.gov