Cancer chemoprevention by dietary polyphenols: promising role for epigenetics

A Link, F Balaguer, A Goel - Biochemical pharmacology, 2010 - Elsevier
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …

New modes of action for endocrine-disrupting chemicals

MM Tabb, B Blumberg - Molecular endocrinology, 2006 - academic.oup.com
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that
mimic or block the transcriptional activation elicited by naturally circulating steroid hormones …

Downregulation of SNCA expression by targeted editing of DNA methylation: a potential strategy for precision therapy in PD

B Kantor, L Tagliafierro, J Gu, ME Zamora, E Ilich… - Molecular therapy, 2018 - cell.com
Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson's disease
(PD), while normal physiological levels of SNCA are needed to maintain neuronal function …

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic …

SL Archer, G Marsboom, GH Kim, HJ Zhang, PT Toth… - Circulation, 2010 - Am Heart Assoc
Background—Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn …

Growth hormone regulation of sex-dependent liver gene expression

DJ Waxman, C O'Connor - Molecular endocrinology, 2006 - academic.oup.com
The liver is a primary target for the action of GH, a pituitary protein hormone that regulates a
broad range of physiological processes, including long bone growth, fatty acid oxidation …

Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases

K Yoon, SJ Kwack, HS Kim, BM Lee - Journal of Toxicology and …, 2014 - Taylor & Francis
Endocrine-disrupting chemicals (EDC), including phthalates, bisphenol A (BPA),
phytoestrogens such as genistein and daidzein, dichlorodiphenyltrichloroethane (DDT), and …

Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer

Y Zhang, R Wang, H Song, G Huang, J Yi, Y Zheng… - Cancer letters, 2011 - Elsevier
Aberrant DNA methylation is a common phenomenon in human cancer. The aims of this
study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in …

Parabens in male infertility—Is there a mitochondrial connection?

RS Tavares, FC Martins, PJ Oliveira… - Reproductive …, 2009 - Elsevier
Parabens are widely used as preservatives in many foods, cosmetics, toiletries, and
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use …

Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples

BK Barták, A Kalmár, B Péterfia, ÁV Patai, O Galamb… - Epigenetics, 2017 - Taylor & Francis
Aberrant methylation is one of the most frequent epigenetic alterations that can contribute to
tumor formation. Cell-free DNA can originate from tumor tissue; therefore, the evaluation of …

Impacts of epigenetic processes on the health and productivity of livestock

M Wang, EM Ibeagha-Awemu - Frontiers in Genetics, 2021 - frontiersin.org
The dynamic changes in the epigenome resulting from the intricate interactions of genetic
and environmental factors play crucial roles in individual growth and development …