Phosphonic acids are rarely found in drug candidate molecules, despite the potential of this
functional group to provide unique binding interactions with a target enzyme or receptor …

The search for new anti-hepatitis C virus (HCV) therapeutics continues as the current
treatment, consisting of PEGylated IFN-α and ribavirin, is of limited efficacy, nonspecific and …

A novel strategy was used in the design of self-assembled drug delivery systems (SADDSs)
in this study. The nanoassemblies of an amphiphilic adefovir lipid derivative were prepared …

A series of 5-substituted 3-phosphonylated isoxazolidines have been obtained via
cycloaddition of N-methyl-C-(diethoxyphosphoryl) nitrone with N-heteroaromatic …

Up to date, there are two types of drugs approved to treat hepatitis B: interferons and
nucleos (t) ide analogues. However, the therapies are limited in the clinical context because …

Hepatitis C virus (HCV) infects an estimated 170–200 million people worldwide and is
associated with life-threatening liver diseases such as cirrhosis and hepatocellular …

Progression of a molecule with interesting pharmacological properties into clinical
development is frequently hampered by undesirable characteristics such as poor …

Antiviral nucleosides are compounds that are used against viruses, such as human
immunodeficiency virus (HIV) and hepatitis C virus (HCV). To act as therapeutic agent, the …

Byl vypracován rozsáhlý přehled současného stavu výzkumu na poli vývoje fosfonátů
acyklických nukleosidů (FAN), který cituje 196 prací v abstrahovaných časopisech. Byla …

Les nucléosides représentent avec plus de 40 composés approuvés la pierre angulaire des
chimiothérapies antivirales. Leur émergence progressive depuis maintenant prés de 50 ans …